EPIGENETIC MECHANISMS OF SOY ISOFLAVONES IN PROSTATE CANCER TREATMENT

Soy intake has been associated with a lower risk of prostate cancer. Soybeans contain isoflavones, genistein, daidzein and glycitein, which have shown anti-cancer effects in cell culture animal studies. Recently clinical trials soy isoflavones humans also promising results. anti-oxidant anti-inflammatory properties may be important for their anticancer effects. In addition, recent studies significant epigenetic isoflavones. DNA methylation histone acetylation reported to modified by genistein. Therefore, genistein similar the commonly used cancer drugs, demethylating agent 5-azacytidine deacetylase inhibitor drug Vorinostat. Thus, combining chemotherapeutic agents potential benefits. Furthermore, radiation therapy conventional therapeutic activate NF-kappa-B resulting resistance chemotherapy radiation. Genistein is potent NF-kappa-B, thereby sensitize cells therapy. While sensitizing radiation, at same time protect normal tissues from adverse are due oxidative inflammatory Clinical investigating potentiating as well toxicity reducing warranted. androgen deprivation therapy, such metabolic syndrome, hypertension, diabetes cardiovascular disease could potentially prevented isoflavones.